Treanda: Adult Dosing

Dosage forms: IV

chemotherapy

uses, dosing may vary

Info: for all uses, refer to institution protocols and pkg insert prior to prescribing; see pkg insert for toxicity-related dose adjustments

CLL

100 mg/m^2 IV qd x2 doses

Info: 28-day cycle, may repeat for up to 6 cycles

renal dosing

see below

mild-mod impairment: caution advised; CrCl <40: avoid use

hepatic dosing

see below

mild impairment: caution advised; AST or ALT 2.5-10x ULN and billirubin 1.5-3x ULN, or bilirubin >3x ULN: avoid use

Treanda: Peds Dosing

This information is currently unavailable or not applicable for this drug.

Treanda: Contraindications/Cautions

• hypersens. to drug/class/compon.
• hypersens. to mannitol
• caution if myelosuppression

Treanda: Drug Interactions

Contraindicated

• anthrax vaccine

• smallpox vaccine (live vaccinia virus)

• vaccines, live

Avoid/Use Alternative

• acetaminophen/caffeine/CNS depressant combos

• alefacept

• aspirin/caffeine/CNS depressant combos

• atropine/hyoscyamine/phenobarbital/scopolamine

• barbiturates

• caffeine

• carbamazepine

• ciprofloxacin

• ergotamine/caffeine

• fluvoxamine

• methoxsalen

• mexiletine

• natalizumab

• omeprazole

• palifermin

• propafenone

• rifampins

• ritonavir

• ticlopidine

• zileuton

Monitor/Modify Tx

• allopurinol

• azathioprine

• cidofovir

• clozapine

• colony-stimulating factors

• dexrazoxane

• flucytosine

• ganciclovir

• hydroxyurea

• mycophenolate mofetil

• primaquine

• pyrimethamine

• pyrimethamine/sulfadoxine

• zidovudine

Caution Advised

• vaccines/toxoids

Treanda: Adverse Reactions

Serious Reactions

• myelosuppression
• neutropenia
• thrombocytopenia
• anemia
• leukopenia
• lymphopenia
• febrile neutropenia
• pneumonia
• sepsis
• anaphylactic/anaphylactoid rxns (rare)
• tumor lysis syndrome
• skin toxicity, severe
• bullous exanthema

Common Reactions

• myelosuppression
• neutropenia
• thrombocytopenia
• anemia
• leukopenia
• fever
• nausea/vomiting
• diarrhea
• fatigue
• asthenia
• rash
• hyperuricemia
• weight loss
• lymphopenia
• nasopharyngitis
• chills
• infection
• pruritus
• cough
• infusion rxn
• febrile neutropenia
• malaise
• weakness
• dry mouth
• somnolence
• constipation
• headache
• mucosal inflammation
• stomatitis
• HTN

Treanda: Safety Monitoring

Pregnancy: D

Lactation: Unsafe

Avoid Pregnancy: use reliable contraception during tx and x3mo after D/C in women of childbearing potential and in men w/ partners of childbearing potential

Monitoring Parameters: CBC w/ diff, Plt frequently; blood chemistries incl. K, uric acid

Treanda: Pharmacology

Metabolism: hydrolysis primarily, liver; CYP450: 1A2 substrate

Excretion: feces (90%); Half-life: 40min

Class: Alkylating Agents

Mechanism Of Action
alkylates and crosslinks DNA (nitrogen mustard)

Treanda: Manufacturer/Pricing

Manufacturer: Cephalon, Inc. DEA/FDA: Rx

Treanda: Patient Education

Patient education material for this drug is not currently available.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.

Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides.

The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Treanda: Pill Pictures

This information is currently unavailable or not applicable for this drug.